Endocrine Abstracts

Growth hormone receptor (GHR) internalisation plays a crucial role in GHR activation and signalling by controlling the availability of the receptor for binding growth hormone (GH), regulating the intensity and duration of the GH signal, initiating unique signalling pathways, and maintaining homeostasis in the GH signalling pathway. GHR internalisation occurs mainly through clathrin-mediated endocytosis. Upon GH binding, the GHR undergoes ubiquitination, which is a signal for i...

GH is an important regulator of longitudinal growth in children and metabolism in adults. GH is used for treatment deficiency disorders in both children and adults. GH treatment is safe and well tolerated. However, its clinical use is limited to daily s.c. injections which poses a challenge for both the patients and the physicians and has prompted research into alternative approaches to GH treatment.NNC0195-0092 is a hGH derivative conjugated with an alb...